The iPRECIO® programmable pump is an advanced infusion device for drug delivery applications in mice, rats and larger animals. With versatile programming functions and a refillable reservoir, this implantable infusion pump enables full control over dosing studies and empowers researchers to execute even the most complex dosing protocols, including multiple bolus dosing, variable/constant delivery, escalating drug administration, and more.
With the user-friendly iPRECIO management software, the infusion profile is programmed and downloaded to the pump’s memory chip. Pump refilling is possible via percutaneously accessible septum, enabling researchers to change solutions or refill the pump during the course of the study. Two iPRECIO pump versions are now available: the iPRECIO SMP-200 is suitable for implantation in rats and larger animals, and the iPRECIO SMP-300 can be implanted in mice and larger animals.
The technology driving the infusion process is a patented "Rotary Finger" mechanism. A micro-motor inside the pump slowly revolves in a clockwise direction turning the cam with its four projections. In each quarter rotation, a single cam projection sequentially pushes up each of the seven finger pins. This continuous cycle compresses the liquid filled tube, creating a peristaltic-like movement of the fluid. As the solution moves through the tube, it is expelled from the pump reservoir into the test subject. The accuracy of the iPRECIO pump is +/- 5%. Each pump is calibrated at factory for maximum precision. A unique ID and Calibration Factor is shown in the program window during the programming phase.
A unique benefit of the iPRECIO pump is its ability to be refilled after implantation, while in the animal. Test solutions can be exchanged or replenished via percutaneous access to the pump through a re-sealable septum. This feature enables researchers to perform chronic infusion studies without having to replace empty pumps, eliminating the need for multiple surgeries during the course of the study. Pump refilling can extend the duration of the iPRECIO SMP-200 pump to up to six months (at 1 ul/hr flow rate), at which point the installed battery is depleted. The iPRECIO reservoir is elastic and its geometry allows gentle palpation to approximate the level of fluid in the reservoir and confirm pump performance. Furthermore, the iPRECIO management software calculates refill timing so the user can adjust the volume as needed throughout the study.